Diane Simeone, MD
Principal Investigator and Executive Committee Chair
New York University Langone Health
Laura and Isaac Perlmutter Professor of Surgery, Department of Surgery; Professor, Department of Pathology; Director, Pancreatic Cancer Center and The Early Detection and Prevention Center; Associate Director, Translational Research, Perlmutter Cancer Center
Dr. Simeone is the Laura and Isaac Perlmutter Professor of Surgery and Pathology, Director of the Pancreatic Cancer Center, and also serves as Associate Director for Translational Research for the Perlmutter Cancer Center. An internationally renowned pancreatic surgeon and researcher with a long-standing career focus on the treatment of pancreatic neoplasms, she has been the recipient of numerous NIH grants investigating the molecular mechanisms driving pancreatic metastasis and the development of novel, more effective therapeutic strategies to treat pancreatic cancer patients. She has a large clinical practice taking care of patients with pancreatic neoplasms and those at elevated risk of the disease. She first discovered pancreatic cancer stem cells, identified ATDC as a novel oncogene in human cancers, and first defined unique populations of fibroblasts in pancreatic cancer. She has been an innovator in the development of therapeutic clinical trials for pancreatic cancer and is the Principal Investigator of Precision Promise, an exciting new adaptive platform clinical trial consortium focused on next-generation clinical trials for patients with pancreatic cancer. She also spearheads the PRECEDE Consortium, an international collaboration of 37 centers to study a large cohort of individuals at heritable risk for pancreatic cancer. She served as chair of the scientific and medical advisory board of the Pancreatic Cancer Action Network, member of the NCI Pancreatic Cancer Task Force and is past-president of the Society of University Surgeons and the American Pancreatic Association. Dr. Simeone is a member of the National Academy of Medicine.